老年原发性高血压患者脉压与血尿酸相关性分析及辛伐他汀对其影响

目的 探讨脉压与血尿酸的关系以及辛伐他汀对血脂正常的老年原发性高血压(PH)患者脉压与血尿酸水平的影响.方法 选择85例PH患者及健康体检者74例作为研究对象,检测不同高血压分级患者脉压的变化,及不同脉压患者血尿酸水平的变化.将85例原发性高血压患者按机械抽样法随机分为常规降压加辛伐他汀组(43例,辛伐他汀20 mg/d)及常规降压加安慰剂组(42例),治疗6个月后观察两组脉压与血尿酸水平的变化,并做相关性分析.结果 高血压分级越高,脉压越大,血尿酸水平也越高;单因素回归分析表明,脉压与血尿酸水平呈正相关(r=0.87,P<0.05).常规降压加辛伐他汀组治疗6个月后,脉压及血尿酸水平均显著降低(P<0.05),而常规降压加安慰剂组脉压及血尿酸水平有降低趋势,但与治疗前比较差异无统计学意义(P>0.05);两组治疗6个月后脉压及血尿酸水平比较差异有统计学意义(P<0.05).结论 老年PH患者随着脉压增大,血尿酸水平亦逐渐增高,与脉压呈正相关.在血脂正常的老年PH患者,常规降压治疗加辛伐他汀不仅能调节血脂,而且还能降低脉压及血尿酸水平,提示他汀类药物是老年PH患者重要的治疗药物.

Effect of simvastatin on pulse pressure and blood uric acid in aged primary hypertension patients

Objective To discuss the relationship between pulse pressure and blood uric acid and the effect of simvastatin on pulse pressure and blood uric acid in aged primary hypertension (PH) patients with normal cholesterol.Methods Eighty-five patients with PH were divided into two groups randomly,routine group (using drugs only to lower blood pressure) and simvastatin group (simvastatin was added).Six months later,blood uric acid and pulse pressure was measured again.Results With the development of hypertension,there was statistical difference on pulse pressure and blood uric acid between hypertension grade 3 and grade 1 or grade 2 (P < 0.05).With the increase of pulse pressure,the trend of blood uric acid increase was distinct,and blood uric acid level was positively related with pulse pressure by correlation analyses(r = 0.87,P< 0.05).The pulse pressure and blood uric acid was decreased after treatment compared with that before treatment in simvastatin group (P < 0.05),but there was no significant difference before and dter treatment in routine group (P >0.05).There was significant difference after treatment between two groups (P< 0.05).Conclusions With the increasing of pulse pressure,there is a significant raise in blood uric acid.Blood uric acid is positively related with pulse pressure by correlation analyses.Simvastatin is a drug used to lower cholesterol,and it could also be used to reduce pulse pressure and blood uric acid in aged PH patients with normal cholesterol.