异甘草酸镁联合熊去氧胆酸治疗自身免疫性肝炎肝硬化失代偿期的疗效观察

目的:观察异甘草酸镁联合熊去氧胆酸对于自身免疫性肝炎肝硬化失代偿期炎症活动的控制作用。方法:选择我院2008—08-2011—08期间收治的自身免疫性肝炎或重叠综合征的患者58例,随机分为实验组和对照组,实验组(n=29)用异甘草酸镁(天晴甘美)200m g加入5%葡萄糖注射液250mL中静脉滴注,1次/d,同时口服熊去氧胆酸750m g/d,对照组(n=29)只用熊去氧胆酸治疗,分别连用4周。结果:两组疗效均显著,肝功能生化指标及免疫学指标与治疗前相比差异有统计学意义(P<0.01),治疗结束后生化指标下降程度两组相比也有统计学意义(P<0.05或P<0.01),实验组明显优于对照组。结论:异甘草酸镁联合熊去氧胆酸对于控制自身免疫性肝炎肝硬化失代偿期有显著作用。

The efficiency of magnesium isoglycyrrhizinate combined with ursodeoxycholic acid in treatment of autoimmune hepatitis cirrhosis with decompensated liver

Objective：The objective is to investigate the therapeutic effect of magnesium isoglycyrrhizinat on the discompensation stage cirrhosis of autoimmune hepatitis.Methods：Fifty-eight patients were randomly assigned to a treatment group（n=29） and a control group（n=29）.Patients in the treatment group received magnesium isoglycyrrhizinate 200mg once on a daily basis,while oral administration of ursodeoxycholic acid 750mg/day.Patients in the control group received compound gly cyrrhizin 200 mg once daily.The Course takes 4 weeks,and was observed in terms of the change of clinical manifestations,biochemical and immunological indexes.Results：Patients in both groups showed therapeutic effect with statistical significance（P0.01）.In both groups,after treatment,the degree of biochemical indicators declined significantly in the experimental group than the control group（P0.05 or P0.01）.Conclusion：The result shows that glycyrrhizic acid is an effective drug for controlling inflammation activity of the discompensation stage cirrhosis of autoimmune hepatitis and magnesium isoglycyrrhizinate is a more effective and safer agent than compound glycyrrhizin.It may be used extensively.