| 阿昔洛韦/赖氨酸壳聚糖纳米粒的理化性质考察 |
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| 引用本文： | 李佳琳,孟萍,刘春年,颜承云.阿昔洛韦/赖氨酸壳聚糖纳米粒的理化性质考察[J].黑龙江医药科学,2012,35(3):21-22. |
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| 作者姓名： | 李佳琳 孟萍 刘春年 颜承云 |
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| 作者单位： | 佳木斯大学药学院,黑龙江佳木斯,154007 |
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| 摘 要： | 目的：考察阿昔洛韦/赖氨酸壳聚糖纳米粒的理化性质。方法：利用激光粒度分析仪,透射电镜,扫描电镜;高效液相色谱仪等测定载药纳米粒的形态、粒径、包封率和载药量,并考察载药纳米粒的体外释放行为。结果：微球呈类圆形,具有明显的核壳;载药的粒子平均粒径大小为107.96nm;包封率为（61.24±0.68）%;载药量为（15.36±0.65）%;体外释放符合Higuchi模型。结论：阿昔洛韦/赖氨酸壳聚糖纳米粒理化性能具有良好的稳定性,符合实验设计要求。
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| 关 键 词： | 阿昔洛韦 赖氨酸壳聚糖 纳米粒 理化性质 |
Evaluation of physicochemical properties for acycl ovir/lysine-chitosan nanoparticles in vitro |
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| LI Jia-lin
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MENG Ping
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LIU Chun-nian
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YAN Cheng-yun.Evaluation of physicochemical properties for acycl ovir/lysine-chitosan nanoparticles in vitro[J].Heilongjiang Medicine and Pharmacy,2012,35(3):21-22. |
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| Authors: | LI Jia-lin MENG Ping LIU Chun-nian YAN Cheng-yun |
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| Institution: | (College of Pharmacy,Jiamusi University,Jiamusi 154007,China) |
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| Abstract: | Objective:To investigate physical and chemical properties of nanoparticles.Methods:To determine particle size,encapsulation efficiencies,drug loading capacity and release behavior of the drug by laser particle size analyzer,transmission electron microscopy,scanning electron microscopy and high pressure liquid chromatography.Results:The nanoparticles was spherical with obvious nuclear shell,the nanoparticles had average diameter of 107.96nm,encapsulation efficiency of(61.2±0.68) %,drug loading capacity of(15.36±0.65)% and the in virto release effect was correspond with Higuchi Equation.Conclusion:The particle stability of acyclovir lysine-chitosan nanoparticles was tranquilization. |
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| Keywords: | acyclovir lysine-chitosan nanoparticles physical and chemical properties |
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