Gene constellation of live influenza A vaccines

Summary The genotypic composition of several H₃N₂ vaccinal strains made from PR/8/34 and different wild isolates has been determined. The results suggested that specific gene constellations at the level of the 3 largest RNA fragments, coding the 3 polymerase proteins are responsible for their consistent attenuation.Part of this study was supported by a grant from the Institut pour l'Encouragement de la Recherche Scientifique dans l'Industrie et l'Agriculture (I.R.S.I.A.).