Gene constellation of live influenza A vaccines |
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Authors: | G. Florent |
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Affiliation: | (1) Immuno-Biology Department Smith Kline-RIT sa., Rixensart, Belgium |
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Abstract: | Summary The genotypic composition of several H3N2 vaccinal strains made from PR/8/34 and different wild isolates has been determined. The results suggested that specific gene constellations at the level of the 3 largest RNA fragments, coding the 3 polymerase proteins are responsible for their consistent attenuation.Part of this study was supported by a grant from the Institut pour l'Encouragement de la Recherche Scientifique dans l'Industrie et l'Agriculture (I.R.S.I.A.). |
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