Plasma Cystatin C in the Dog: Reference Values and Variations with Renal Failure |
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Authors: | J.-P. Braun A. Perxachs D. Pe´CHEREAU F. De La Farge |
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Affiliation: | (1) Biochimie & UMR 181 Physiopathologie et Toxicologie Expe′rimentales, Ecole Nationale Ve′te′rinaire, Toulouse, France, FR;(2) Clinique Ve′te′rinaire des Pyre′ne′es, Pau, France, FR;(3) Biochimie, CHU Rangueil, Toulouse, France, FR |
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Abstract: | Cystatin C is a low-molecular-mass acid protein produced at a constant rate by all nucleated cells and cleared by glomerular filtration. In human medicine it is considered to be a better indicator of renal failure than creatinine. Plasma (Pl-) cystatin C measurements in 179 clinically healthy dogs, using an immunoturbidimetric procedure for human cystatin C, showed a Gaussian distribution with an upper limit of 1.3 mg/l. There were no differences between the sexes. Pl-cystatin C was slightly lower in 1–8-year-old adults than in younger or older dogs. It was also lower in dogs weighing less than 15 kg than in heavier ones. Meals produced a dramatic decrease in Pl-cystatin C that lasted for up to 9h. Pl-cystatin C was elevated in 98% of dogs with renal insufficiency, even in some cases where the Pl-creatinine was normal. Cystatin C may therefore be a useful indicator of renal insufficiency in clinically relevant dogs with borderline P1-creatinine values. |
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Keywords: | :Cystatin C – Dogs – Plasma – Reference interval – Renal insufficiency |
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