TangoPlus扩张性分析及其在心血管模型中的可行性

目的:探讨TangoPlus FullCure 930w的扩张性，并评估其在心血管模型中的可行性。方法:根据心血管磁共振图像，利用3D打印对一名受试的降主动脉解剖结构进行建模，并使用TangoPlus进行快速原型。印刷该模型的壁厚分别为0.6、0.7、0.8、1.0和1.5 mm，血管腔保持恒定；且模型分别以垂直和水平方向印刷，共得到10个样本。通过监测压力变化，同时逐渐增加和减少内部体积，从而进行依从性试验。生产出一种适合连接在体外试验模拟循环回路中的患者特异性顺应性主动脉模型。打印出需行肺动脉瓣置换术患者的右心室流出道（RVOT），以便对器械插入进行物理测试并评估患者经皮肺动脉瓣介入的适用性。结果:对于壁厚0.6 mm，材料的扩张性为（6.5×10-3） mmHg-1；对于壁厚1.5 mm，材料的扩张性为（3.0×10-3） mmHg-1。垂直方向打印的型号相比水平方向的型号更符合要求。顺应性主动脉发育不全的快速原型和RVOT解剖模型都是可行的；器械插入RVOT模型成功。结论:TangoPlus适用于制造动脉模型，与PolyJet打印兼容，确保具有代表性的解剖结构建模，制造快速且廉价。该材料还可以用于探索非均匀壁厚印刷模型的吸引力。然而，该材料似乎太硬，无法模拟更符合要求的全身性静脉系统。

Expansibility of TangoPlus and its feasibility in cardiovascular model

Objective To explore the expansibility of Tango Plus Full Cure 930 w and evaluate its feasibility in cardiovascular model.Methods According to the cardiovascular magnetic resonance image, the anatomical structure of the descending aorta of a subject was modeled by 3 D printing and a rapid prototyping was completed using TangoPlus. The model was printed with different wall thickness(0.6, 0.7, 0.8, 1.0 and 1.5 mm), while the vessel lumen remained constant;the model was also printed in vertical and horizontal directions, and finally a total of 10 samples were obtained. Compliance testing was performed by monitoring pressure changes while gradually increasing or decreasing the internal volume. A patient-specific compliance aortic model suitable for the attachment to a simulated circulation circuit in an in vitro assay was produced. The right ventricular outflow tract(RVOT) in patients requiring pulmonary valve replacement was printed for carrying out physical tests on device insertion and assessing the suitability of percutaneous pulmonary valve implantation. Results The expandability of Tango Plus for wall thickness of 0.6 mm and 1.5 mm were(6.5×10^-3) mm Hg^-1 and(3.0×10^-3) mm Hg^-1, respectively. The model printed in the vertical direction was better than that printed in the horizontal direction. Both rapid prototyping for compliance aortic hypoplasia and RVOT anatomic model were proved to be feasible. The device was also successfully inserted into RVOT model. Conclusion TangoPlus is suitable for the manufacture of arterial model and is compatible with Poly Jet printing, which can ensure the modeling of representative anatomical structures,with the advantages of rapid manufacture and low cost. The material can be also used for exploring the attractiveness of models printed with non-uniform wall thickness. However, the material appears too hard to simulate a more desirable systemic venous system.