Fully automated preparation of n.c.a. 4-[18F]fluorobenzoic acid and N-succinimidyl 4-[18F]fluorobenzoate using a Siemens/CTI chemistry process control unit (CPCU). |
| |
Authors: | Jan Marik Julie L Sutcliffe |
| |
Affiliation: | Department of Biomedical Engineering, University of California Davis, 451 East Health Sciences Drive, CA 95616-5294, USA. |
| |
Abstract: | The widely used bifunctional labeling reagent 4-[18F]fluorobenzoic acid ([18F]FBA) and its activated form N-succinimidyl 4-[18F]fluorobenzoate ([18F]SFB) were prepared using a modified Siemens/CTI chemistry process control unit (CPCU) double vessel [18F]FDG module. The products were obtained with a radiochemical yield greater than 99% with decay corrected yields of 77+/-5% (n=4) for [18F]FBA and 46+/-5% (n=4) for [18F]SFB. The presented synthetic procedure is highly reproducible and fully automated. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |