高剂量表柔比星为主的联合化疗方案治疗48例晚期胸部恶性肿瘤

目的：评价高剂量表柔比星（表阿霉素）联合其他化疗药物治疗晚期胸部肿瘤的疗效及毒副反应。方法：48例可评价晚期胸部肿瘤中非小细胞癌32例；乳腺癌11例；纵隔恶性淋巴瘤5例。分别应用EMP[表柔比星（EPI）100mg/m^2联合丝裂霉素（MMC)6mg/m^2及顺铂（DDP）60mg/m^2]治疗非小细胞肺癌；应用CEF[环磷酰胺（CTX）600mg/m^2联合表柔比星100mg/m^2及氟尿嘧啶（5－FU）800mg/m^2]治疗乳腺癌。应用CEOP[环磷酰胺600mg/m^2联合表柔比星100mg/m^2、长春新碱（VCR）1mg/m^2及强的松60mg/m^2]治疗纵隔恶性淋巴瘤。3－4周重复。结果：非小细胞肺癌总有效率56．3％；乳腺癌总有效率72．7％；纵隔恶性淋巴瘤总有效率100％。白细胞减少为主要毒副反应，发生率为93．8％。未见明显心脏毒性。结论：高剂量表柔比星治疗晚期胸部恶性肿瘤安全有效。

High-dose epirubicin combination therapy in the treatment of 48 cases with advanced chest malignant tumors

Purpose:To estimate the curative effects and side effects obtained from high-dose epirubicin (EPI) combination therapy in the treatment of advanced chest malignant tumors. Methods:Forty-eight cases with advanced chest malignant tumor(32 cases with non-small-cell lung cancer; eleven cases with breast cancer and five cases with mediastinal malignant lymphomas) were treated with the combination therapy of high-dose EPI. Results:The response rate in non-small-cell lung cancer was 56.3%, in breast cancer was 72.7%, in mediastinal malignant lymphomas was 100%. The most frequent toxicities were neutropenia.Conclusions:The combined chemotherapy of high-does EPI is an effective and safe treatment in advanced chest malignant tumor.