Oligomenorrhoea in adolescents with type 1 diabetes mellitus: relationship to glycaemic control |
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Authors: | Anna Deltsidou Chryssoula Lemonidou Vassiliki Matziou |
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Affiliation: | a School of Nursing Studies, Technological Educational Institute, 3rd Km Old National Road of Lamia-Athens, Lamia 35100, Greece b Faculty of Nursing, University of Athens, Papadiamantopoulou 123, Athens 11527, Greece c Department of Electrical Engineering, Technological Educational Institute, 3rd Km Old National Road of Lamia-Athens, Lamia 35100, Greece |
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Abstract: | ObjectiveTo investigate oligomenorrhoea in adolescents with type 1 diabetes and the possible relationship with glycaemic control.Study designThe study group consisted of 81 female adolescents with type 1 diabetes whose mean age was 15.0 years (range 12-18). The control group consisted of 205 healthy adolescents with a mean age of 15.5 years (range 12-18). Data on menstruation were collected by two parallel self-administered questionnaires. Oligomenorrhoea was defined as having a menstrual cycle longer than 36 days throughout the past year (5-6/year). The metabolic control of diabetes was evaluated by calculating the mean value of HbA1c during the past year.ResultsAge of menarche was greater for adolescents with type 1 diabetes (12.2 ± 1.4 vs. 11.7 ± 1.2, p < 0.000) compared to healthy age-matched controls. Logistic regression analysis with oligomenorrhoea as the dependent binary variable revealed an odds ratio equal to 7.8 (95% CI 3.411-17.853) for adolescents with type 1 diabetes (p < 0.000). Finally, a second logistic regression analysis, concerning only adolescents with type 1 diabetes and with the same binary variable, estimated an odds ratio of 4.8 (95% CI 1.784-13.057, p < 0.002) for HbA1c, and an odds ratio of 5.3 (95% CI 1.821-15.130, p < 0.002) for the frequency of hypoglycaemia.ConclusionIn adolescents with type 1 diabetes, menarche occurs later and oligomenorrhoea is more frequent. The relative risk of having oligomenorrhoea is greater when there is an increased value of HbA1c or when hypoglycaemia is more frequent. |
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Keywords: | Menstrual disorders Oligomenorrhoea Amenorrhoea Type 1 diabetes HbA1c |
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