|
|||||
|
|
Detection of P-glycoprotein in human leukemias using monoclonal antibodies |
|
| Authors: | J. Mattern T. Efferth M. Bak A. D. Ho M. Volm |
| Affiliation: | (1) Department of Experimental Pathology, German Cancer Research Center, Im Neuenheimer Feld 280, D-6900 Heidelberg, Federal Republic of Germany;(2) Guest Scientist from the National Institute of Oncology, Budapest, Hungary;(3) Department of Internal Medicine and Policlinic V, University of Heidelberg, D-6900 Heidelberg, Federal Republic of Germany |
| Abstract: | Summary Overexpression of a Mr 170,000 membrane glycoprotein (P-glycoprotein) is consistently associated with multidrug resistance in cell lines. Two monoclonal antibodies (Mab) against P-glycoprotein (265/F4 and C 219) were used to examine tumour samples from patients with leukemias for evidence of P-glycoprotein overexpression. High levels of P-glycoprotein (>5% positive cells) were detected with both antibodies in samples from 3 out of 18 patients suggesting that a multidrug resistant phenotype may also occur in human leukemias. |
| Keywords: | P-glycoprotein Leukemia Multi-drug resistance Monoclonal antibody |
| 本文献已被 SpringerLink 等数据库收录！ | |