年轻宫颈癌患者的临床病理学特征分析

目的探讨年轻妇女宫颈癌的临床病理特征。方法回顾分析2005年9月～2010年2月收治的≤35岁的68例宫颈癌患者的临床病理资料，随机选择同期收治的〉35岁的30例宫颈癌患者作为对照，并采用免疫组化SP法检测比较两组Survivin、P27蛋白表达的差异，分析比较两组的临床病理特征。结果青年组早期宫颈癌的比例显著高于对照组（Х^2=6．54，P〈0.05）；瘤体直径≥4cm，青年组所占比例与对照组比较，差异有显著性（Х^2=8．62，P〈0．01）；腺癌比例，青年组明显高于对照组（Х^2=7．93，P〈0．01）；青年组的淋巴结转移率、深间质浸润和HPV感染阳性率均明显高于对照组（Х^2=4．79、8．85、9．46，P〈0．05和P〈0．01）；青年组脉管累及率与对照组比较差异无显著性（Х^2=0．75，P〉0．05）；Survivin的表达量青年组较对照组明显升高（Х^2=5．28，P〈0．05）；P27在两组之间的表达量无统计学意义（Х^2=0．24，P〉0．05）。结论35岁以下宫颈癌具有临床期别早、腺癌比例高及瘤体大的临床特点和相对高危的病理因素。

The Study of Clinical Pathological Variables of Cervical Cancer in Young Women

Objective To explore the clinical pathological variables of cervical cancer in young women. Methods Between 2005 and 2010,68 cases of cervical cancer under 35 years of age were treated.30 cases of cervical cancer over 35 years of age were chosen unrandomly as control group.Survivin and P27 were detected by SP. The clinical pathological variables was analyzed. Result8 The younger patients were characterized by a higher rate of bulky lesion,ad ,lymph node metastases,deep stroma invasin ,the expression of Survivin than those in control group. There was no significant difference in lymphovascular space involvement and the expression of P27 for two groups. Conclusion The features of cervical cancer in young women under 35 years old have a high rate of early stage,bulky lesion,higher rate of adenocarcinoma and higher risk factors in pathology.