膀胱移行细胞癌的CT表现与Ki-67、VEGF和MVD表达的相关性

目的]探讨膀胱移行细胞癌（BTCC）的CT表现与Ki-67、血管内皮生长因子（VEGF）和微血管密度（MVD）表达的关系。方法]对41例经手术病理证实的BTCC，采用LDP免疫组化法，检测肿瘤标本中Ki-67、VEGF和MVD的表达，并分析其与术前CT征象的关系。结果]Ki-67LI与VEGF、Ki-67LI与MVD、VEGF与MVD呈显著性正相关（r值分别为0．548、0．603、0．705，P均〈0．001）。Ki-67LI、VEGF和MVD表达与肿瘤呈分叶状、肿瘤多发、膀胱壁增厚、浆膜受侵、邻近器官受累等CT征象均有关（P〈0．05）。结论]BTCC的CT征象与Ki-67LI、VEGF和MVD表达密切相关，当肿瘤有分叶征、肿瘤多发、相邻膀胱壁增厚、浆膜层受侵、邻近器官受累等CT征象时，提示肿瘤可能有较高的恶性程度、浸润能力及较差的预后。

The Relationship Between CT Features and Expression of Ki-67,VEGF and MVD in Bladder Transitional Cell Carcinoma

Purpose] To investigate the relationship between CT features and the expression of Ki-67, vascular endothelial growth factor (VEGF) and the microvessel density (MVD) in bladder tran-sitional cell carcinoma(BTCC). Methods] The expression of Ki-67, VEGF and MVD was detected by labeled dextran polymer (LDP) immunohistochemically in 41 cases with pathologically proved BTCC. The correlation between preoperative CT signs and expression of Ki-67, VEGF and MVD was retrospectively analyzed. Results] Ki-67 labeling index (Ki-67LI) was positively correlated with expression of VEGF, Ki-67LI and MVD as well as VEGF and MVD (r=0.548, 0.603, 0.705, P<0.001). Ki-67LI, VEGF and MVD value were related to tumor with lobulated sign, multiple tu-mors, thickened neighboring urinary bladder wall, serous membrane infiltration and surrounding or-gans involvement (P<0.05). Conclusion] The CT signs of BTCC are closely correlated to their Ki-67LI, VEGF and MVD values. In addition, the BTCC with one or more CT signs of the lobulated sign, multiple tumor, thickened neighboring bladder wall, serous membrane or/and surrounding or-gans involvement indicates higher malignant, degree, high invasive potential and worse prognosis than that without those signs.