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Primary cultured fibroblasts derived from patients with chronic wounds: a methodology to produce human cell lines and test putative growth factor therapy such as GMCSF |
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| Authors: | Harold Brem Michael S Golinko Olivera Stojadinovic Arber Kodra Robert F Diegelmann Sasa Vukelic Hyacinth Entero Donald L Coppock Marjana Tomic-Canic |
| Institution: | (1) Department of Surgery, Division of Wound Healing & Regenerative Medicine, New York University School of Medicine, New York, NY, USA;(2) Tissue Engineering, Regeneration, Repair Program, Laboratory of Tissue Repair, Hospital for Special Surgery of the Weill Medical College of the Cornell University, New York, NY, USA;(3) Department of Dermatology, Miller School of Medicine, University of Miami, Miami, USA;(4) Department of Biochemistry and Molecular Biology, Virginia Commonwealth University Medical Center., Richmond, VA, USA;(5) Ross University School of Medicine, Dominica, West Indies;(6) Coriell Cell Repositories, Coriell Institute for Medical Research, Camden, NJ, USA |
| Abstract: | BackgroundMultiple physiologic impairments are responsible for chronic wounds. A cell line grown which retains its phenotype from patient wounds would provide means of testing new therapies. Clinical information on patients from whom cells were grown can provide insights into mechanisms of specific disease such as diabetes or biological processes such as aging. |
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