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Human umbilical cord blood-derived mesenchymal stem cells promote regeneration of crush-injured rat sciatic nerves |
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| Authors: | Mi-Ae Sung Hun Jong Jung Jung-Woo Lee Jin-Yong Lee Kang-Mi Pang Sang Bae Yoo Mohammad S Alrashdan Soung-Min Kim Jeong Won Jahng Jong-Ho Lee |
| Institution: | 1, 3, 5 1 Department of Craniofacial Structure & Functional Biology, School of Dentistry, Seoul National University, Seoul, Republic of Korea 2 Department of Occupation and Environment, Postgraduate College of Medicine, Konkuk University, Choong-ju, Republic of Korea 3 Department of Oral & Maxillofacial Surgery, School of Dentistry, Seoul National University, Seoul, Republic of Korea 4 Department of Dentistry, Oral and Maxillofacial Surgery, Ajou University School of Medicine, Suwon, Republic of Korea 5 Dental Research Institute, Seoul National University, Seoul, Republic of Korea |
| Abstract: | Several studies have demonstrated that human umbilical cord blood-derived mesenchymal stem cells can promote neural regeneration following brain injury. However, the therapeutic effects of human umbilical cord blood-derived mesenchymal stem cells in guiding peripheral nerve regeneration remain poorly understood. This study was designed to investigate the effects of human umbilical cord blood-derived mesenchymal stem cells on neural regeneration using a rat sciatic nerve crush injury model. Human umbilical cord blood-derived mesenchymal stem cells (1 × 10 6 ) or a PBS control were injected into the crush-injured segment of the sciatic nerve. Four weeks after cell injection, brain-derived neurotrophic factor and tyrosine kinase receptor B mRNA expression at the lesion site was increased in comparison to control. Furthermore, sciatic function index, Fluoro Gold-labeled neuron counts and axon density were also significantly increased when compared with control. Our results indicate that human umbilical cord blood-derived mesenchymal stem cells promote the functional recovery of crush-injured sciatic nerves. |
| Keywords: | human umbilical cord blood-derived mesenchymal stem cells sciatic nerve crush injury Fluoro Gold stem cells peripheral nerve regeneration regeneration neural regeneration |
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