| 一起肺鼠疫暴发流行的病原学研究及流行病学分析 |
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| 引用本文： | 慕有,魏绍振,金丽霞,杨汉青,赵小龙,谢辉,王梅,赵忠智,张爱萍,罗玉丽,杨永海.一起肺鼠疫暴发流行的病原学研究及流行病学分析[J].现代预防医学,2010,37(7). |
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| 作者姓名： | 慕有 魏绍振 金丽霞 杨汉青 赵小龙 谢辉 王梅 赵忠智 张爱萍 罗玉丽 杨永海 |
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| 作者单位： | 青海省地方病预防控制所鼠疫预防控制科病原室,西宁,811602 |
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| 摘 要： | 目的]研究一起人间肺鼠疫暴发流行的鼠疫菌分离株其生物学特性、基因特征等。拟从分子流行病学的角度分析传染源和传播关系。方法]对8株于鼠疫患者(尸体)分离的鼠疫菌进行糖醇类酵解试验;检测其毒力、毒力因子、质粒、生物型、基因型;运用分子流行病学方法分析本次流行的传染源。结果]8株鼠疫菌全部为甘油+、阿胶糖+、脱氮+,生物型为古典型。具备强毒鼠疫菌的4个毒力决定因子,为FraI+、VW+、PstI+、Pgm+;对小白鼠的最小致死量介于50～1000个菌,为强毒株;具备我国多数鼠疫菌所携带的6、45和65Mdal质粒;基因组型全部为10型。结论]根据分子流行病学和现场流行病学调查结果证实,此次肺鼠疫暴发流行来自同一个传染源。
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| 关 键 词： | 鼠疫菌 生物学 基因 流行病学 |
EPIDEMIOLOGICAL ANALYSIS AND ETIOLOGY RESEARCH ON PNEUMONIC PLAGUE OUTBREAK |
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| MU You,WEI Shao-zhen,JIN Li-xia,et al..EPIDEMIOLOGICAL ANALYSIS AND ETIOLOGY RESEARCH ON PNEUMONIC PLAGUE OUTBREAK[J].Modern Preventive Medicine,2010,37(7). |
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| Authors: | MU You WEI Shao-zhen JIN Li-xia |
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| Institution: | MU You,WEI Shao-zhen,JIN Li-xia,et al.(Qinghai Institute for Endemic Diseases Prevention , Control,Xining 811602,China) |
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| Abstract: | Objective] To research on biological and genetic characteristics of yersinia pestis isolated from pneumonic plague outbreak,to analyze its infection source and relationship of transmission by molecular epidemiology.Methods] Went on sugar alcohols glycolysis test on 8 strains yersinia pestis isolated from plague patient(body),detected its virulence,the virulence factor,plasmid,biotype and genotype,analyzed its infection source by molecular epidemiology method.Results] These 8 strains yersinia pestis were ... |
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| Keywords: | Yersinia pestis Biology Genetics Epidemiology |
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