Changes in the sensitivity of smooth muscle to neurotransmitter during acute morphine treatment and its association with analgesia |
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Authors: | S Ramaswamy N P Pillai V Gopalakrishnan M N Ghosh |
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Affiliation: | Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605006, India |
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Abstract: | Acute in vivo administration of morphine to mice produced dose- and time-dependent subsensitivity to acetylcholine in ileum and supersensitivity to norepinephrine in vas deferens. These responses were specific to the agonist as potassium chloride-induced responses were not altered. A correlation was observed between the analgesia and the sensitivity changes produced by morphine. The sensitivity changes were mediated through opiate receptors as naloxone antagonised the effect of morphine. |
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Keywords: | Morphine Sensitivity Analgesia Naloxone |
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