帕米膦酸二钠合并化疗治疗28例骨转移癌的疗效观察

目的：观察帕米膦酸二钠合并化疗对骨转移引起疼痛的疗效，生活质量的改善和不良反应。方法：对54例临床确诊为骨转移癌的患者随即分成两组。对照组（26例，给予常规化疗）和治疗组（28例，在对照组的基础上加用帕米膦酸二钠）进行临床观察。结果：治疗组总有效率82．1％，对照组的总有效率57．7％，具有显著性差异（P〈0．05）；各主要系统的不良反应治疗组较对照组轻。结论：帕米膦酸二钠合并化疗对骨转移癌有良好的止痛效果且不良反应少。

Observing Pamidronate Disodium and Chemotherapy's Curative Effect on Osseous Metastasis

Objective: observing pamidronate disodium and chemotherapy's curative effect on pain caused by osseous metastasis,its function on improvement of life quality and side reaction as well.Methods:deviding 54 sufferers who are diagnosed clinically as osseous metastasis into two groups:matchedgroup(26 cases,giving common chemotherapy);treatment group(28 cases,adding pamidronate disodium based on common chemotherapy)and has clinical observation.Results: total effective percentage of treatment group is 82.1 % while that of matched group is 57.7 %,the former's effectiveness is superior to the latter(P<0.05)and has no undesirable side effects to the main systems.Conclusions: pamidronate disodium has favourable effects to kill pain caused by osseous metastasis and has light side effect.