胰岛素抵抗、血清瘦素水平与子痫前期-子痫关系的研究

目的:研究子痫前期-子痫时胰岛素抵抗与血清瘦素水平之间的关系,探讨胰岛素抵抗与瘦素在子痫前期-子痫发病中的作用。方法:采用酶联免疫吸附法(BLISA)、放射免疫法及葡萄糖氧化酶法检测50例子痫前期-子痫患者及50例正常妊娠妇女(对照组)的血清瘦素、胰岛素及血糖水平,采用血糖和血胰岛素乘积的倒数来表示胰岛素敏感指数,并分析胰岛素抵抗、血清瘦素水平与子痫前期-子痫的相关性。结果:子痫前期-子痫患者存在明显胰岛素抵抗,且与疾病严重程度呈正相关,血清瘦素水平增加导致子痫前期-子痫患者胰岛素抵抗程度升高。结论:孕妇血清瘦素水平变化与子痫前期发病及病情发展有关。

Study on relationship of insulin resistance , leptin and preeclampsia- eclampsia

Objective:To study the relationship between insulin resistance and the level of leptin of patients with preeclampsia-eclampsia , and investigate the role of insulin resistance and leptin in the pathogenesis of preeclampsia-eclampsia.Methods:The levels of leptin and insulin in serum and fast blood glucose were detected from 50 patients with preeclampsia-eclampsia(preeclampsia-eclampsia group)and 50 normal pregnant women (control group) by enzyme linked immunosorbent assay(ELISA), radioimmunoassay and glucose oxidase method, insulin sensitivity index were demonstrated by the reciprocal of (blood glucose × insulin), and the relationship of insulin resistance, the level of leptin and preeclampsia-eclampsia was analyzed.Results:The preeclampsia was more serious, the degree of insulin resistance was more increased;Insulin resistance of preeclampsia-eclampsia patients increased maybe caused by the increase of serum level of leptin.Conclusion:The changes of levels of leptin are related to the occurrence and development of preeclampsia-eclampsia.