疏肝活血药方对家兔主动脉平滑肌细胞脂过氧化物含量和超氧化物歧化酶活性的影响

动脉平滑肌细胞内脂过氧化物含量增加，超氧化物歧化酶活性减弱，与动脉弱样硬化的发生有着重要的关系。本文实验通过对家兔主动脉平滑肌细胞进行体外培养，观察到中药疏肝活血可以显著降低平滑肌细胞内脂过氧化物含量，明显提高超氧化物歧化酶活性。

Effect of Chinese Drug Recipe, Removing Stagnancy of Vital Energy of Liver and Invigorating Blood Circulation, on Content of Lipid Peroxide and Activity of Superoxide Dismutase in Aortic Smooth Muscle Cell of Rabbits

The etiology pathology etc of atherosclerosis (As) have been studied widely for many years. From the traditional medicine viewpoint,the mechanism of stasis exsisted in As. So the Chinese drug recipe of removing stagnancy of vital energy of the liver and invigorating blood circulation was subjucted in treatment of As. From the molecullar level of cytobiology, the effect of Chinese drugs on content of lipid peroxide (LPO) and activity of superoxide dismutase (SOD) were studied in vitro cultured SMC of rabbit aorta. The results showed that content of LPO in SMC were lower in Chinese drugs group than that in the control group (P<0. 01), activity of SOD in SMC were higher in Chinese drugs group than that in the control group (P< 0. 01). This Chinese drug recipe may obviously ruduce the content LPO of SMC, raise the activity of SOD, protect the normal function,metabolism and complete constitution. Thus, the Chinese drug recipe reduce the pathological changes of make it tend to motionless.