盐酸纳洛酮(金尔伦)治疗急性颅脑损伤25例疗效观察

目的:探讨早期应用盐酸纳洛酮(金尔伦)对急性颅脑损伤的临床疗效。方法:对入选的46例急性颅脑损伤患者在常规治疗的基础上,随机分为两纽,治疗组25例,用金尔伦治疗,每天8mg,以21例同等伤情未用金尔伦药物治疗病例为对照组,于用药1天、7天后观察GCS评分、血内皮素水平、经颅多谱勒、脑电图的变化情况,对照组及治疗组结果均进行统计学分析。结果:金尔伦治疗组GCS评分明显升高,血内皮素水平下降,脑血管痉挛发生率及脑电波异常率显著下降,各项指标均明显优于对照组(P<0.05)。结论:早期应用金尔伦能有效改善急性脑外伤患者的临床症状,减轻脑血管痉挛,降低伤残率,促进神经功能恢复,改善预后,对急性颅脑损伤患者有明显治疗效果。

Clinical Study on Naloxone in Treatment of 25 Patients With Acute Craniocerebral Trauma

OBJECTIVE:To study the therapeutic effect of naloxone early to administer on acute craniocerebral trauma.METHODS: 46 patients with acute craniocerebral trauma were randomly divided into two groups: Besides routine treatment, 25 patients were treated with naloxone in a dose of 8mg q .d . ,21 patients did not treated with naloxone .The GCS score,plasma ET levels, transcranial Doppler(TCD) ,and electroencephalogram(EEG) were measured 1 day,7 days after the administration. The results were analyzed statistically .RESULTS: In treatment group,GCS score was obviously improved,the level of ET in plasma was reduced;brain vasospasm incidence rate was lower and abnormal rate of EEG was lower in comparison with those in control group.As a result,the detecting indices in treating group were superior to those in the control group(F<0.05) .CONCLUSION: Naloxone early to administer may improve the consciousness, reduce brain vasospasm, decrease disability rate and improve living quality in the moderate and severe craniocerebral trauma.