PET imaging in the surgical management of pediatric brain tumors |
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Authors: | Benoit Pirotte Francesco Acerbi Alphonse Lubansu Serge Goldman Jacques Brotchi Marc Levivier |
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Institution: | 1.Department of Neurosurgery, H?pital Erasme,Université Libre de Bruxelles,Brussels,Belgium;2.PET–Cyclotron/Biomedical Unit, H?pital Erasme,Université Libre de Bruxelles,Brussels,Belgium |
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Abstract: | Objective The present article illustrates whether positron-emission tomography (PET) imaging may improve the surgical management of
pediatric brain tumors (PBT) at different steps.
Materials and methods Among 400 consecutive PBT treated between 1995 and 2005 at Erasme Hospital, Brussels, Belgium, we have studied with 18
F-2-fluoro-2-deoxy-D-glucose (FDG)–PET and/or L-(methyl-11C)methionine (MET)–PET and integrated PET images in the diagnostic workup of 126 selected cases. The selection criteria were
mainly based on the lesion appearance on magnetic resonance (MR) sequences. Cases were selected when MR imaging showed limitations
for (1) assessing the evolving nature of an incidental lesion (n = 54), (2) selecting targets for contributive and accurate biopsy (n = 32), and (3) delineating tumor tissue for maximal resection (n = 40). Whenever needed, PET images were integrated in the planning of image-guided surgical procedures (frame-based stereotactic
biopsies (SB), frameless navigation-based resections, or leksell gamma knife radiosurgery).
Results Like in adults, PET imaging really helped the surgical management of the 126 children explored, which represented about 30%
of all PBT, especially when the newly diagnosed brain lesion was (1) an incidental finding so that the choice between surgery
and conservative MR follow-up was debated, and (2) so infiltrative or ill-defined on MR that the choice between biopsy and
resection was hardly discussed. Integrating PET into the diagnostic workup of these two selected groups helped to (1) take
a more appropriate decision in incidental lesions by detecting tumor/evolving tissue; (2) better understand complex cases
by differentiating indolent and active components of the lesion; (3) improve target selection and diagnostic yield of stereotactic
biopsies in gliomas; (4) illustrate the intratumoral histological heterogeneity in gliomas; (5) provide additional prognostic
information; (6) reduce the number of trajectories in biopsies performed in eloquent areas such as the brainstem or the pineal
region; (7) better delineate ill-defined PBT infiltrative along functional cortex than magnetic resonance imaging (MRI); (8)
increase significantly, compared to using MRI alone, the number of total tumor resection and the amount of tumor tissue removed
in PBT for which a total resection is a key-factor of survival; (9) target the resection on more active areas; (10) improve
detection of tumor residues in the operative cavity at the early postoperative stage; (11) facilitate the decision of early
second-look surgery for optimizing the radical resection; (12) improve the accuracy of the radiosurgical dosimetry planning.
Conclusions PET imaging may improve the surgical management of PBT at the diagnostic, surgical, and post-operative steps. Integration
of PET in the clinical workup of PBT inaugurates a new approach in which functional data can influence the therapeutic decision
process. Although metabolic information from PET are valid and relevant for the clinical purposes, further studies are needed
to assess whether PET-guidance may decrease surgical morbidity and increase children survival. |
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Keywords: | Pediatric brain tumors Positron-emission tomography Stereotactic biopsy Navigation Infiltrative tumors Functional imaging Image-guidance Tumor resection |
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