Intratumoral FOXP3VEGFR2 regulatory T cells are predictive markers for recurrence and survival in patients with colorectal cancer |
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Authors: | Hiroyuki Suzuki Hideya Onishi Takashi Morisaki Masao Tanaka Mitsuo Katano |
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Institution: | 1. Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;2. Fukuoka General Cancer Clinic, Fukuoka, Japan;3. Department of Surgery and Oncology, Kyushu University, Fukuoka, Japan |
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Abstract: | Previously, we have shown that CD8+T/FOXP3+ cell ratio but not FOXP3+ cell number alone is an independent prognostic factor for colorectal cancer. In the present study, we evaluated whether the number of intratumoral FOXP3+VEGFR2+ (itFOXP3+VEGFR2+) T cells alone could be a predictive factor for survival prognosis in patients with colorectal cancer. Distribution of regulatory T cells (Tregs) at tumor sites derived from 88 patients with primary colorectal cancer was fluorescence-immunohistochemically examined. Relatively low number of itFOXP3+VEGFR2+ cells significantly correlated with poor disease-free survival (DS) and overall survival (OS); multivariate analysis indicated that number of itFOXP3+VEGFR2+ cells is an independent predictive and prognostic factor of DS and OS while neither intratumoral FOXP3+ cell number nor intratumoral FOXP3+VEGFR2− cell number alone showed significant correlation with DS or OS. These results suggest that FOXP3+VEGFR2+ may be a better predictive Treg marker than FOXP3+ alone for recurrence and survival in patients with colorectal cancer. |
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Keywords: | Tregs regulatory T cells FOXP3 Forkhead box P3 VEGFR2 vascular endothelial growth factor receptor2 itFOXP3+VEGFR2+ intratumoral FOXP3+ VEGFR2+ itFOXP3+ intratumoral FOXP3+ itFOXP3+VEGFR2&minus intratumoral FOXP3+VEGFR2&minus |
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