血管内皮生长因子C和D2-40在结肠癌中的表达及临床意义

目的探讨血管内皮生长因子C(VEGF-C)及D2-40在结肠癌中的表达及临床意义。方法取85例人结肠癌组织样本,应用免疫组织化学法,检测VEGF-C及D2-40的表达,并与其临床特征作相关分析。结果85例结肠癌组织中VEGF-C阳性表达率(54.1%)及微淋巴管数量(LMVD)与正常结肠组织间差异有显著性意义,且与淋巴结转移和临床分期相关,而与患者的年龄、性别、大小、浸润深度和分化程度无关,VEGF-C的表达与LMVD呈正相关(r=0.543,P<0.05)。结论结肠癌中VEGF-C的高表达与淋巴管生成、淋巴结转移和预后有关,联合检测VEGF-C和D2-40的表达对判断结肠癌的早期淋巴道转移、预后及指导临床治疗有重要的意义。

The Expressions of VEGF-C and D2-40 in Colon Cancer and Their Clinical Significance

Objective To approach the relationship between VEGF-C and D2-40 expressions in colon carcinoma and their association with clinicopathologic features.Methods The expressions of VEGF-C and D2-40 in 85 samples of colon cancer tissues were analyzed with immunohistochemistry. Results Of the 85 specimens,the positive expression of VEGF-C(54.1%) and Lymphatic vessel density(LMVD) were signifieantly higher than those in normal colonic tissues(P<0.05),and were correlated to lymph node metastasis and Duke's stage(P<0...