心肌挫伤后心肌标志物测定的临床意义

目的 观察心肌挫伤患者在48h内心肌标志物含量的变化及判断心肌挫伤的程度。方法 对28例心肌挫伤患者在48h内不同时间分别采集静脉血,测定肌红蛋白(Myo)和肌酸激酶同功酶质量(CK-MB)、肌钙蛋白I(c Tnl)及心肌酶谱(LDH、AST)等心肌标志物含量。结果 伤后8h血清中Myo、CK-MB、eTn-I及LDH、AST含量均升高,其中Myo、CK-MB及LDH、AST在伤后8h升高明显(P<0.01):在伤后24hcTn I升高最为明显,而Myo、CK-MB和LDH、AST含量有所下降,但仍高于正常参考值。结论心肌标志物的联合测定在判断心肌挫伤中具有重要意义,cTnI的特异性高于Myo、CK-MB和LDH、AST。

Clinical Significance of the myocardium markers in sera of patients with myocardium contusion

Objective To investigate the changes of the myocarduyn markers within 48 hours in patients with myocardiuln contusion to judge the degree of myocardium contusion.Method 28 patients with myocardium contusion were continuously measured the myocardium markers myoglobin(Myo),creatine kinase MB(CK-MB),cardiac troponin I (cTn I),lactate dehydrogenase(LDH) and aspar-tate aminotransferase(AST) in sera at different lime within 48 hours.Results Myo,CK-MB,cTn 1、LDH and AST all increased clearly after myocardium contusion 8 hours(P<0.01).But cTn I went up highest after 24 hours after myocardium contusion,while Myo,CK-MB,LDH and AST went somewhat down though they were all beyond the upper limit of the reference values.Conclusions It showed that there was important significance for judgement the patients with myocardium contusion by combined detection the myocardium markers.The speciality of cTn I among them was higher than Myo,CK-MB,LDH and AST