Occult hepatitis B virus infection in Thai blood donors |
| |
Authors: | Louisirirotchanakul Suda Oota Sineenart Khuponsarb Kalayanee Chalermchan Wilai Phikulsod Soisaang Chongkolwatana Viroje Sakuldamrongpanish Tasanee Kitpoka Pimpun Chielsilp Pimol Tanprasert Srivilai Tirawatnapong Thaweesak Wasi Chantapong;Working Group for NAT Study in Thai Blood Donations |
| |
Institution: | Department of Microbiology and Transfusion Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. sudaloui@yahoo.com |
| |
Abstract: | BACKGROUND: An evaluation by the National Blood Center, the Thai Red Cross Society, of two commercial multiplex nucleic acid tests (NATs; the Chiron PROCLEIX ULTRIO test and the Roche Cobas TaqScreen MPX test) for screening Thai blood donors for hepatitis B virus (HBV), hepatitis C virus, and human immunodeficiency virus Type 1 identified 175 HBV NAT–reactive/hepatitis B surface antigen (HBsAg)‐negative donors. The classification of the HBV infection of these donors was confirmed by follow‐up testing. STUDY DESIGN AND METHODS: Index samples were tested for HBV serologic markers and HBV viral loads were determined. Donors were followed for up to 13 months and samples were tested with both NAT assays and for all HBV serological markers. RESULTS: Of 175 HBV NAT–yield donors, 72 (41%) were followed. Based on the follow‐up results, the majority of donors who were followed had an occult HBV infection (66.7%), followed by donors with a primary, acute infection (26.4%). The majority of donors in this latter group (20.8%) were in the window period. Three donors (4.2%), who were anti‐HBs positive, had a reinfection or breakthrough infection. CONCLUSION: The majority of donors detected during routine screening, who were HBsAg negative and NAT reactive, had an occult HBV infection, thus validating the decision to introduce NAT for blood donations in Thailand. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|