| EZH2与肿瘤的关系 |
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| 引用本文： | 白洁,帅晓明,陶凯雄.EZH2与肿瘤的关系[J].国外医学(肿瘤学分册),2012(3):182-186. |
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| 作者姓名： | 白洁 帅晓明 陶凯雄 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院胃肠外科,武汉430022 |
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| 摘 要： | 果蝇zeste基因增强子同源物2（EZH2）通过催化组蛋白H3第27位赖氨酸三甲基化抑制基因表达。在前列腺癌、乳腺癌、膀胱癌及胃癌等多种肿瘤中都有高表达，与肿瘤的恶性进程、侵袭性、转移能力关系密切。随着对其在肿瘤中分子功能、上下游调控机制和临床病理特点的深入了解，EZH2有望做为靶点，为肿瘤治疗提供新的途径。
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| 关 键 词： | 肿瘤 治疗 EZH2 |
EZH_2 gene and cancer |
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| BAI Jie,SHUAI Xiao-ming,TAO Kai-xiong.EZH_2 gene and cancer[J].Foreign Medical Sciences (Cancer Section),2012(3):182-186. |
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| Authors: | BAI Jie SHUAI Xiao-ming TAO Kai-xiong |
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| Institution: | . Department of Gastrointestinal Surgery, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China |
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| Abstract: | EZH2 is the catalytic subunit of polycomb repressive complex 2 （ PRC2）, which represses gene expression by catalyzing lysine 27 of histone H3. It is overexpressed in prostate cancer, breast cancer, bladder cancer, gastric cancer and several other cancers. There is a close correlation between overexpression of EZH2 and progression of malignancy, invasion and migration of cancer cells. With a thorough understanding of the function, up and down stream regulatory mechanism and clinicopathological features, EZH2 will be expected to as a target and provide a new way for the treatment of cancers. |
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| Keywords: | Neoplasms Therapy EZH2 |
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