乳腺癌ABVS冠状面图像特征与分子分型的相关性分析

目的：分析经自动乳腺全容积成像(ABVS)所获得的乳腺癌图像冠状面特征与分子分型之间的联系。方法：对153例（157个病灶）经病理证实的乳腺癌患者的ABVS冠状面图像特征及免疫组化结果进行回顾性分析，探讨乳腺癌ABVS冠状面图像特征与分子分型的相关性。结果：不同分子分型的乳腺癌在ABVS冠状面上显示的边界、微钙化及间接征象方面均有统计学差异（P<0.05），微钙化在Luminal B型和Her-2过表达型中占比例较多（69.4%、77.3%），汇聚征在Luminal A型最常见（43.7%），三阴型更容易出现清晰的边界（27.8%）。四种分子分型的组织病理学特征及边缘形态之间的差异无统计学意义（P>0.05）。结论：乳腺癌ABVS图像冠状面特征与四种亚型之间有一定的相关性。

A correlation between the coronal plane imaging features of ABVS and molecular subtypes of breast cancer

Objectives: To investigate the correlation between the coronal plane imaging features obtained by an automated breast volume scanner (ABVS) and different molecular subtypes of breast cancer.Methods: Data from 153 breast cancer patients (157 tumors) confirmed pathologically were analyzed. Each tumor was examined by ABVS for coronal plane imaging features and by immunohistochemical analysis to obtain the molecular subtype. The clinicopathological characteristics and imaging features of different molecular subtypes were compared.Results: We found significant difference in boundary, microcalcifications and indirect signs on the coronal plane between the four subtypes (P<0.05).The Luminal B and Her-2 subtypes were more commonly seen with microcalcifications (69.4% and 77.3%,respectively). Retraction phenomenon occurred more frequently in Luminal A subtype(43.7%) than in others(all P<0.05).Clear boundary was more often found in Triple-Negative subtype(27.8%).No statistically significant difference was found in clinicopathological characteristics and margin shape among the four subtypes(all P>0.05).Conclusions: The coronal plane imaging features have a certain correlation with the four breast cancer subtypes.