胸苷磷酸化酶在乳腺癌中的表达及其临床意义

目的　研究胸苷磷酸化酶(TP)在乳腺癌中的表达与癌组织的临床病理特征和肿瘤内微血管密度 (IMVD)的关系。方法　对82例乳腺癌标本及17例正常乳腺组织进行免疫组化染色测定TP的表达情况;通过 CD34免疫组化染色检测乳腺癌组织中的IMVD。结果　乳腺癌细胞中的TP表达阳性率高于正常乳腺组织(P <0.05);TP高表达组中IMVD明显高于TP低表达组(P<0.05);乳腺癌Ⅰ、Ⅱ、Ⅲ级癌组织之间的TP表达率有 明显差异(P<0.05)。结论　乳腺癌TP表达与其组织学分级和血管生成有关。

Expression of Thymidine Phosphorylase in Breast Carcinoma and its Clinical Significance

Objective To study the relationship of thymidine phosphorylase (TP) with intratumoral microvessel density (IMVD) and the clinical and pathological features in breast carcinoma.Methods The expression of TP in 82 cases with breast carcinoma and 17 cases with normal breast tissue were measured by immunohistochemistry.Intratumoral microvessel density was immunohistochemically detected using anti-CD34 monoclonal antibody.Results The level of TP of cancer cell was more than that of normal breast tissue cell (P<0.05).Moreover,IMVD of the TP-high-expression group was significantly higher than the TP-low-expression group (P<0.05).There is evident difference between the level of TP in different pathological grades (P<0.05).Conclusion The expression of TP in breast carcinoma is closely correlated with angiogenesis and the clinical and pathological features.