Alterations in [Met]- and [Leu]enkephalin and neurotensin content in basal ganglia induced by the long-term administration of dopamine agonist and antagonist drugs to rats期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Alterations in [Met]- and [Leu]enkephalin and neurotensin content in basal ganglia induced by the long-term administration of dopamine agonist and antagonist drugs to rats

Authors:	Maria L. De Ceballos Susan Boyce Peter Jenner C. David Marsden

Affiliation:	MRC Movement Disorder Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry and King's College Hospital Medical School, Denmark Hill, London SE5, U.K.

Abstract:	Treatment of rats for 18 months with trifluoperazine increased [Met⁵]- and [Leu⁵]enkephalin and neurotensin content in striatum and nucleus accumbens. However, in substantia nigra the content of [Met⁵]enkephalin was decreased, [Leu⁵]enkephalin unchanged and that of neurotensin increased. Administration of L-DOPA plus carbidopa, bromocriptine or pergolide for 12 months decreased [Met⁵]enkephalin (except bromocriptine) and neurotensin, but not [Leu⁵]enkephalin, levels in striatum. L-DOPA decreased and bromocriptine increased neurotensin levels in substantia nigra. But neurotensin levels in nucleus accumbens were unaffected.

Keywords:	Neuroleptic drugs [Met⁵]enkephalin [Leu⁵]enkephalin, Neurotensin Long-term treatment
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