Chemokines are elevated in plasma after strenuous exercise in humans |
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Authors: | Kenneth Ostrowski Thomas Rohde Sven Asp Peter Schjerling Bente Klarlund Pedersen |
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Institution: | (1) The Department of Infectious Diseases M7721, Rigshospitalet, 2200 KBH N, Denmark e-mail: bkp@rh.dk Tel.: +45-3545-7797; Fax: +45-3545-6648, DK;(2) Copenhagen Muscle Research Centre, Rigshospitalet, Afs. 7652, 2200 KBH N, Denmark, DK |
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Abstract: | During the last few years much attention has been paid to the chemokines. Chemokine receptors are necessary to render a target
permissive for infection by the human immunodeficiency virus (HIV) and high concentrations of chemokines have been shown to
protect against the progression of HIV disease towards death. In the present study, we investigated the capability of strenuous
exercise to induce elevated plasma concentrations of the chemokines interleukin (IL)-8, macrophage inflammatory protein (MIP)-1α
and MIP-1β. Eight male athletes completed the Copenhagen Marathon 1997. Blood was sampled before, immediately after the run
and every 30 min during a 4 h recovery period. Plasma chemokine concentrations were measured using enzyme-linked immunosorbent
assays. The IL-8, MIP-1α and MIP-1β concentrations all peaked 0.5 h after the run when they were 6.7-fold, 3.5-fold and 4.1-fold
increased, respectively. The elevated concentrations of chemokines in plasma after exercise could have implications for HIV-infected
individuals; a possibility that needs further investigation.
Accepted: 21 September 2000 |
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Keywords: | Running Marathon Human immunodeficiency virus (HIV) Chemokine |
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