| 金匮肾气丸延缓衰老作用的实验研究 |
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| 作者姓名： | 周坤福 王明艳 |
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| 作者单位： | 南京中医药大学基础医学院 |
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| 摘 要： | 目的：探讨金匮肾气丸延缓衰老作用的机理。方法：用环磷酰胺（ＣＰＰ）诱致小鼠骨髓细胞ＤＮＡ损伤，以微核（ＭＮ）和姐妹染色单体互换（ＳＣＥ）为指标，观察温补肾阳、延缓衰老代表方金匮肾气丸的抗ＤＮＡ损伤作用。结果：金匮肾气丸对由环磷酰胺所致ＤＮＡ损伤具有良好的拮抗作用。结论：提高机体抗ＤＮＡ损伤能力可能是金匮肾气丸延缓衰老作用的主要机理所在。
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| 关 键 词： | 金匮肾气丸 抗衰老 微核 姐妹染色单体互换 实验研究 |
Mechanism of Jinkui Shenqi Pill in Preventing Aging |
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| Authors: | Zhou Kunfu Wang Mingyan Chen Quanliang Wu Haitao Zao Mingfeng Zhang Xu |
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| Abstract: | OBJECTIVE:To investigate into the mechanism of Jinkui shenqi Pill in preventing aging. METHOD:Cyclophosphamide were used to cause damage of DNA in mice and the effect of the pill against DNA damage was observed, with MN and SCE as indexes. RESULT:Jinkui Shenqi Pill has good antagonizing effect for DNA damage caused by cyclophosphamide. CONCLUSION:The mechanism of this pill in preventing aging lies in its effect in enhancing the body's ability to prevent DNA damage. |
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| Keywords: | Jinkui Shenqi Pill prevent aging micronucleus sister chromatid exchange experimental research |
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