乳糖酶治疗轮状病毒肠炎患儿的临床疗效观察

目的探讨乳糖酶治疗轮状病毒肠炎患儿中乳糖酶缺乏的临床疗效。方法对本院儿科2013年1月～2013年12月腹泻患儿进行轮状病毒检测,应用改良斑氏法作粪还原糖及pH值测定,其中还原糖2＋～3＋或还原糖＋,pH值〈5.5作为研究对象,随机分为治疗组和对照组,对照组给予补液、纠酸、补锌、补充活菌制剂、平常饮食等综合治疗,治疗组在对照组基础上加用乳糖酶口服。结果治疗组总有效率96.2%,对照组总有效率80.4%。经χ^2检验,两组总有效率比较差异具有统计学意义（P〈0.01）,治疗组平均痊愈天数为（4.13±1.22）d,对照组平均痊愈天数为（5.25±1.56）d。两组经t检验,差异具有统计学意义（P〈0.01）。结论乳糖酶治疗轮状病毒肠炎继发乳糖酶缺乏疗效可靠,且无任何副作用,可作为治疗轮状病毒肠炎的常规用药。

Clinical effect of lactase lactase in the treatment of children with rotavirus enteritis deficiency

Objective To investigate the clinical effect of lactase lactase in the treatment of children with rotavirus enteritis deficiency. Methods Choosing children with diarrhea from January 2013 to December 2013 in our hospital for rotavirus detection. We carry out Stool Reducing sugar and pH determination method. We chosen the reducing sugar 2～3 ＋ or reducing sugar＋, pH value〈5.5 as the objects of study. The objects were randomly divided into treatment group and control group, being given combined treatment including fluid infusion, correcting acid, zinc, supplemental probiotics and the normal diet etc.The treatment group was plused lactase orally on the basis of the control group. Results The total effective rate of treatment group was 96.2% and the comparison group total effectiveness was 80.4%. By the chi square test, the total efficiency of two groups had significant difference（P〈0.01）. The treatment group was（4.13±1.22） days average recovery and the control group was（5.25±1.56） days average recovery. By t test, there was significant difference between two groups（P〈0.01）. Conclusion The lactase enzyme has reliable curative effect in the treatment of rotavirus enteritis with secondary lactase deficiency, without any side effects, it can be used as a routine treatment of rotavirus enteritis.