Atrial natriuretic factor in sympathetic ganglia of the rat: dependence on cholinergic innervation |
| |
| Authors: | W Debinski O Kuchel M Nemer N T Buu J Genest |
| |
| Affiliation: | Clinical Research Institute of Montreal, H?tel-Dieu Hospital, Montréal, Québec, Canada. |
| |
| Abstract: | Atrial natriuretic factor is detectable in the peripheral autonomic ganglia of the rat by radioimmunoassay and immunohistochemistry. In the present study, surgical and neurochemical methods were used to evaluate the source of this peptide in sympathetic ganglia. Decentralization of the ganglia and/or central administration of colchicine diminished the atrial natriuretic factor content in para- and prevertebral ganglia. Axotomy did not affect levels of ganglionic atrial natriuretic factor. A messenger ribonucleic acid species hybridizing with rat atrial natriuretic factor complementary deoxyribonucleic acid was not found within the total ribonucleic acid extracted from superior cervical ganglia. These results indicate a direct dependence of ganglionic atrial natriuretic factor on cholinergic innervation. |
| |
| Keywords: | |
|
|
