| 高压氧对新生大鼠缺氧缺血性脑病脑组织匀浆中SOD、GSH-PX及MDA的影响 |
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| 引用本文： | 张丽达,刘家浩,姜素敏,杨胜敏,梁方志,田小香. 高压氧对新生大鼠缺氧缺血性脑病脑组织匀浆中SOD、GSH-PX及MDA的影响[J]. 东南大学学报(医学版), 1998, 0(3) |
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| 作者姓名： | 张丽达 刘家浩 姜素敏 杨胜敏 梁方志 田小香 |
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| 作者单位： | 南京铁道医学院附属医院高压氧室 |
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| 摘 要： | 目的：探讨高压氧（ＨＢＯ）对新生大鼠缺氧缺血性脑病（ＨＩＥ）的影响。方法：将７日龄ＳＤ新生大鼠随机分为对照组、ＨＩＥ组和ＨＢＯ治疗组。在实验第７天后处死动物。测定病侧脑组织匀浆超氧化物歧化酶（ＳＯＤ）、谷胱甘肽过氧化物酶（ＧＳＨ－ＰＸ）和丙二醛（ＭＤＡ）含量。结果：（１）ＨＩＥ模型组ＳＯＤ、ＧＳＨ－ＰＸ活力明显低于对照组（Ｐ＜０．０００３，Ｐ＜０．００６），而ＭＤＡ含量显著高于对照组（Ｐ＜０．００３）；（２）ＨＩＥ组ＨＢＯ治疗１周后，脑组织中ＳＯＤ、ＧＳＨ－ＰＸ活力明显高于未治疗ＨＩＥ组（Ｐ＜０．０００３，Ｐ＜０．００６），而ＭＤＡ含量低于未治疗ＨＩＥ组（Ｐ＜０．００３）。结论：ＨＢＯ能增加ＨＩＥ脑组织内自由基清除酶类的活力，降低局部脂质过氧化物的含量
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| 关 键 词： | 高压氧；缺氧缺血性脑病；氧自由基；大鼠 |
Effects of Hyperbaric Oxygenation on Newborn Rats with Hypoxicischemic Encephalopathy |
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| Zhang Lida,Liu Jahao,Jiang Sumin,Yang Shengmin,Liang Fangzhi,Tian Xiaoxiang. Effects of Hyperbaric Oxygenation on Newborn Rats with Hypoxicischemic Encephalopathy[J]. Journal of Southeast Univ: Medical Sci Ed, 1998, 0(3) |
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| Authors: | Zhang Lida Liu Jahao Jiang Sumin Yang Shengmin Liang Fangzhi Tian Xiaoxiang |
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| Abstract: | Objective:To study the effects of hyperbaric oxygen(HBO) on newborn SD rats with hypoxicischemic encephalopathy(HIE).Methods:The newborn rats were randomized into control group,HIE group and HIE treated with HBO group.The rats were then killed and contents of SOD,GSH-PX and MDA in cerebral homogenate were measured.Results:(1)SOD,GSH-PX activity of HIE were lower than that of control group( P <0.003);(2)SOD,GSH-PX activity in HIE rats treated by HBO became higher than of HIE,MDA value was lower.Conclusion:HBO can decrease the production of the oxygen derived free radicals in brain after HIE. |
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| Keywords: | hyperbaric oxygen free radical hypoxicischemic encephalopathy free radical rats |
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