CDH1 promoter hypermethylation and E-cadherin protein expression in infiltrating breast cancer |
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| Authors: | José Roberto F Caldeira érika C Prando Francisco C Quevedo Francisco A Moraes Neto Cláudia A Rainho Silvia R Rogatto |
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| Affiliation: | (1) Department of Senology, Amaral Carvalho Hospital, Ja?, Sao Paulo, Brazil;(2) Department of Genetics, Institute of Bioscience, Sao Paulo State University, Botucatu, Sao Paulo, Brazil;(3) Department of Pathology, Amaral Carvalho Hospital, Ja?, Sao Paulo, Brazil;(4) NeoGene Laboratory, Department of Urology, Faculty of Medicine, Sao Paulo State University, CEP 18618-000 Botucatu, Sao Paulo, Brazil |
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| Abstract: | Background The E-cadherin gene (CDH1) maps, at chromosome 16q22.1, a region often associated with loss of heterozygosity (LOH) in human breast cancer. LOH at this site is thought to lead to loss of function of this tumor suppressor gene and was correlated with decreased disease-free survival, poor prognosis, and metastasis. Differential CpG island methylation in the promoter region of the CDH1 gene might be an alternative way for the loss of expression and function of E-cadherin, leading to loss of tissue integrity, an essential step in tumor progression. |
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