热疗对食管癌放疗患者T辅助细胞亚型的影响

目的 探讨热疗对食管癌放疗患者T辅助细胞亚型(Th1/Th2)的影响。方法 22例患者随机分2组:单放组10例,常规放疗,总剂量 64~66 Gy,5次/周,共30~33次;综合组12例,除常规放疗外加内生场热疗,2次/周,4~5周。流式细胞仪检测治疗前、后患者外周血Th1/Th2。结果单放组治疗后Th1细胞显著下降(t=5.33,P<0.01);综合组治疗后Th1细胞没有明显变化(t=-1.41, P>0.05)。组间比较:单放组Th1细胞下降(t=4.28,P<0.05)。结论 内生场热疗促使机体由Th2细胞向Th1细胞逆转,调整Th1/Th2细胞平衡。

Influence of hyperthermo-radiotherapy on T helper subgroup for patients with esophageal carcinoma

Objective To evaluate the influence of hyperthermia on T helper subgroup (T help type1/T help type2,Th1/Th2) for patients with esophageal carcinoma.Methods 22 patients of esophageal carcinoma were randomly divided into two groups. Both group patients were treated by external radiation, the total dose was 64-66 Gy/30-33 fractions. Radiotherapy was the only therapy method in group A. Hyperthermia was used twice every week, with 8-10 fractions except for radiotherapy in group B. All patients were phlebotomized at the beginning and the end of radiotherapy for examining Th1/Th2 by flow cytometry.Results Th1 was significantly decreased in group A(t=5.33,P<0.01). All indexes in group B had no difference (t=-1.41, P>0.05). The Th1 in group A was decreased much more than that in group B(t=4.28,P<0.05).Conclusion Hyperthermia could rectify the balance of Th1/Th2.