| HCCR、pERK及pELK1蛋白在胃癌组织中的表达及其相关性 |
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| 引用本文： | 姚林华,;胡奕,;邓中民,;张玲,;张国新.HCCR、pERK及pELK1蛋白在胃癌组织中的表达及其相关性[J].中国现代医生,2014(24):1-3. |
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| 作者姓名： | 姚林华 ;胡奕 ;邓中民 ;张玲 ;张国新 |
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| 作者单位： | [1]湖州师范学院附属第一医院消化内科,浙江湖州313000; [2]湖州师范学院附属第一医院内分泌科,浙江湖州313000; [3]南京医科大学附属第一医院消化内科,江苏南京210000 |
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| 基金项目： | 浙江省医药卫生科技计划项目（2012KYB200）;浙江省湖州市科技局项目（2012YSB15） |
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| 摘 要： | 目的：检查胃癌组织及癌旁组织中HCCR、pERK及pELK1的表达，探讨之间的相关性。方法通过免疫组化方法检测60例胃癌及癌旁组织中HCCR、pERK及pELK1的表达情况。结果 HCCR、pERK及pELK1在胃癌组织中的阳性表达率分别为75.0%（45/60）、73.3%（44/60）及71.7%（43/60），均高于其在癌旁组织中的表达，差异均有统计学意义（P〈0.05）。结论 HCCR、pERK及 pELK1三者之间具有一定的协调表达率，在肿瘤组织中表达明显增高，可用来作为胃癌临床免疫组化的辅助指标。
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| 关 键 词： | 胃癌 HCCR pERK pELK1 |
Expression of HCCR,pERK, pELK1 in gastric cancer and its correlations |
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| Institution: | YAO Linhua,HU Yi,DENG Zhongmin,ZHANG Ling,ZHANG Guoxin (1.Department of Gastroenterology, the First Allifilated Hospital of Huzhou Teachers Collegy, Huzhou 313000, China; 2.Department of Endocrinology, the First Allifilated Hospital of Huzhou Teachers Collegy, Huzhou 313000, China; 3. Department of Gastroenterology, the First Allifilated Hospital of Nanjing Medical University, Nanjing 210000, China) |
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| Abstract: | Objective To explore the expression of HCCR, pERK and pELK1 in gastric cancer tissue and para-carci-noma tissue, and to explove its correlations. Methods In 60 human gastric cancers and their corresponding paraneo-plastic tissuses,the expression of HCCR, pERK and pELK1 were detected by immunohistochemistry. Results The ex-pression of HCCR was 75.0%（45/60）, pERK, and pELK1 were 73.3%（44/60） and 71.7%（43/60）, respectively, and the expression of proteins in gastric tumor were higher than that in paraneoplastic tissues （P〈0.05）. Conclusion The HCCR, pERK and pELK1 are higher expressed in tumor tissues, availably as a auxiliary index for clinical immunohis-tochemistry in gastric cancer. |
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| Keywords: | Gastric cancer HCCR pERK PELK1 |
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