青壮年猝死综合征脑干中缝背核5-羟色胺及5-羟色胺转运体免疫组化研究 |
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引用本文: | 吴华,;唐群,;瞿志雄,;王健,;王兴华.青壮年猝死综合征脑干中缝背核5-羟色胺及5-羟色胺转运体免疫组化研究[J].中国现代医生,2014(15):61-62. |
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作者姓名: | 吴华 ;唐群 ;瞿志雄 ;王健 ;王兴华 |
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作者单位: | [1]湖南省第二人民医院芙蓉司法鉴定中心,湖南长沙410007; [2]湖南中医药大学病理教研室,湖南长沙410208 |
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基金项目: | 湖南省教育厅科研项目(12C0259) |
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摘 要: | 目的 探讨5-羟色胺和5-羟色胺转运体在青壮年猝死综合征脑组织的表达及其意义.方法 运用免疫组织化学S-P法检测10例正常脑组织和8例青壮年猝死综合征脑组织中5-羟色胺和5-羟色胺转运体的表达水平,利用图像分析技术测量阳性细胞的平均光密度值.结果 青壮年猝死征死者脑干中缝背核5-羟色胺的平均光密度值低于正常脑组织,而5-羟色胺转运体的平均光密度值高于正常脑组织,差异均有统计学意义(P<0.05).结论 5-羟色胺及5-羟色胺转运体的变化参与青壮年猝死综合征的发病过程,可作为诊断青壮年猝死综合征的参考指标.
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关 键 词: | 法医病理学 青壮年猝死综合征 5羟色胺 5羟色胺转运体 免疫组化 |
Immunohistochemical study on SMDS dorsal nucleus raphe 5-serotonin and 5-serotonin transporter |
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Institution: | WU Hua, TANG Qun ,QU Zhixiong, WANG Jian, WANG Xinghua ( 1.Furong Judicial Identification Center of the Second People's Hospital of Hunan Province, Changsha 410007,China; 2. Department of Pathology of Hunan University of Chinese Medicine, Changsha 410208, China) |
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Abstract: | Objective To investigate the 5- serotonin and 5-serotonin transporter expression and significance in brain tissue of sudden manhood death syndrome. Methods Used immunohistochemical S-P staining method in 10 cases of normal brain tissues and 8 cases of sudden manhood death syndrome in expression of 5-HT and 5-serotonin transporter in the brain tissue, using image analysis technique to measure the mean optical density of positive cells of value, Re- sults The average optical density of the .5- serotonin in the dorsal nucleus raphe of sudden manhood death syndrome was lower than that in normal brain tissue, and the average optical density of 5-serotonin transporter was higher than that in normal brain tissue, the differences were statistically significant (P 〈 0.05). Conclusion The changes of 5- HT and 5- serotonin transporter were involved in the pathogenesis of sudden manhood death syndrome, which can be used as a reference marker for diagnosis of sudden manhood death syndrome. |
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Keywords: | Forensic pathology Sudden manhood death syndrome 5-serotonin 5-serotonin transporter Immunohisto- chemistry |
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