坦洛新缓释胶囊联合全雄激素阻断治疗晚期前列腺癌伴膀胱出口梗阻的疗效

目的：探讨坦洛新缓释胶囊与全雄激素阻断联合用于晚期前列腺癌伴膀胱出口梗阻的疗效。方法将68例晚期前列腺癌伴膀胱出口梗阻患者随机分为观察组与对照组。两组均接受全雄激素阻断治疗,观察组在此基础上口服坦洛新缓释胶囊0.2 mg,1次/d,疗程均为4个月。结果治疗4个月后,两组QOL及Qmax较治疗前明显上升,IPSS评分、RU和TPSA较治疗前明显减少（P〈0.05或P〈0.01）,且观察组IPSS、QOL、Qmax、RU改善幅度明显优于对照组（P〈0.05）。对照组未发生明显药物不良反应,观察组出现体位性头晕1例,症状较轻。结论坦洛新缓释胶囊联合雄激素阻断能迅速有效地改善晚期前列腺癌患者LUTS症状,提高患者的生活质量,安全、经济。

Efficacy of tamsulosin sustained release capsules combined with maximal androgen blockade in treatment of advanced prostate cancer concurrent with bladder outlet obstruction

Objective To investigate the efficacy of tamsulosin sustained release capsules combined with maximal an-drogen blockade in the treatment of advanced prostate cancer concurrent with bladder outlet obstruction. Methods Six-ty-eight patients with advanced prostate cancer concurrent with bladder outlet obstruction were randomly divided into the observation group and the control group. Both groups received maximal androgen blockade treatment, on the basis of which the observation group received oral tamsulosin sustained release capsules 0.2 mg and once a day. The treat-ment course was 4 months for two groups. Results After 4 months of treatment, QOL and Qmax of two groups elevated significantly than before treatment, and IPSS score, RU and TPSA reduced significantly than before treatment（P〈0.05 or P〈0.01）. And the improvement degrees of IPSS, QOL, Qmax and RU of the observation group were significantly better than those of the control group （P〈0.05）. No obvious drug adverse reactions occurred in the control group and 1 case of mild positional dizziness occurred in the observation group. Conclusion In the treatment of patients with advanced prostate cancer, tamsulosin sustained release capsules combined with maximal androgen blockade can rapidly improve the patients＇ LUTS symptoms, improve the patients＇ quality of life, and is safe and economical.