首页 | 本学科首页   官方微博 | 高级检索  
     

血清学无创肝纤维化检测与肝脏穿刺病理诊断的比较研究
引用本文:王玲娣,;巫露丹,;毛卫林. 血清学无创肝纤维化检测与肝脏穿刺病理诊断的比较研究[J]. 中国现代医生, 2014, 0(24): 90-92
作者姓名:王玲娣,  巫露丹,  毛卫林
作者单位:[1]宁波市鄞州人民医院病理科,浙江宁波315040; [2]宁波市李惠利医院检验科,浙江宁波315040; [3]浙江大学医学院附属第一医院检验科,浙江杭州310003
基金项目:浙江省医药卫生科技计划(2011KYA058)
摘    要:目的:对比分析血清学无创肝纤维化检测与肝脏穿刺病理检测在慢性乙型肝炎临床诊断中的应用及各自具有的优势和劣势。方法选取2012年4月~2013年3月期间我院门诊收治的97例慢性乙型肝炎患者作为本研究的观察对象,分别对患者进行血清学无创肝纤维化检测与肝脏穿刺病理检测,对比两种检测结果。结果所有患者的血清学无创肝纤维化检测指标(PⅢP、Ⅳ-C、HA、LN)与病理分期呈良好的正相关。相关系数显示HA 〉LN〉PⅢP〉Ⅳ-C,提示随着肝纤维化程度加重,肝纤维化检测指标有逐渐升高的趋向,各项指标差异均有统计学意义(P〈0.05)。结论肝脏穿刺病理检测是慢性乙型肝炎患者诊断的“金标准”,但对患者损伤较大。血清学无创肝纤维化检测具有较高的诊断价值,能够减少穿刺活检的数量。

关 键 词:慢性乙型肝炎  肝纤维化  穿刺病理  血清学

comparative study of non-invasive fibrosis serological testing and liver biopsy diagnosis of liver
Affiliation:WANG Lingdi,WU Ludan,MAO Weilin (1.Department of Pathology,Yinzhou People's Hospital of Ningbo City in Zhejiang Province ,Ningbo 315040 ,China; 2.Clinical Laboratory,Lihuili Hospital of Ningbo City in Zhejiang Province ,Ningbo 315040, China;3.Clinical Laborato- ry,the Affiliated First Hospital, Medical College of Zhejiang University, Hangzhou 310003, China)
Abstract:Objective To compare the serological non-invasive liver fibrosis tests and pathological examination in the clinical diagnosis of chronic hepatitis B. Methods Selected 97 patients with chronic hepatitis B in our hospital as the research object and tested non-invasive liver fibrosis tests and liver biopsy pathological examination.Compare the test results of two kinds. Results The serum noninvasive hepatic fibrosis index(PⅢP,Ⅳ-C,HA,LN)showed good positive correlation with pathological stage. The correlation coefficient suggested that with the aggravation of hepatic fibrosis,liv-er fibrosis indexes tended to rise gradually,and the indicators differences were statistically significant (P〈0.05). Con-clusion Liver biopsy in patients with chronic hepatitis B diagnosis detection is the "gold standard" with greater injury. Serological non-invasive liver fibrosis tests has high diagnostic value,can reduce the number of puncture biopsy.
Keywords:Chronic hepatitis B Liver fibrosis Pathology Serology
本文献已被 维普 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号