多发性硬化伴发抑郁症患者血清细胞因子变化研究

目的探讨多发性硬化(MS)伴发抑郁症患者血清细胞因子白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)的变化。方法选取MS伴发抑郁症患者30例,采用酶联免疫吸附试验(ELISA)检测其血清细胞因子IL-1β、IL-6和TNF-α水平,并选择MS不伴抑郁症患者作为对照组进行比较。抑郁症组患者每日给予抗抑郁药物盐酸舍曲林20mg,连续用药4周,观察其疗效及上述细胞因子水平变化。结果 MS伴发抑郁症患者血清IL-1β、IL-6和TNF-α水平均高于MS不伴抑郁症对照组,差异有统计学意义(P0.01);MS伴抑郁症患者应用盐酸舍曲林抗抑郁治疗总有效率为73.3%,治疗后血清IL-1β、IL-6和TNF-α水平均较治疗前下降,差异有统计学意义(P0.05)。结论 IL-1β、IL-6和TNF-α与MS伴发抑郁症存在相关性,提示MS可能通过细胞因子的作用激活了抑郁症的发生。

Research of cytokines change in multiple sclerosis patients with depression

Objective To investigate the change of interleukin （IL）-1beta （IL-1β）,IL-6 and interferon（IFN）-alpha（TNF-α）in multiple sclerosis（MS） with depression.Methods Thirty patients of MS with depression and thirty patients of MS without depression as control were involved in the study.These patients were detected the concentration of IL-1β,IL-6,TNF-α.And the depression patients were detected the concentration of IL-1β,IL-6,TNF-α again after administrating with sertraline four weeks.Results The concentration of IL-1β,IL-6 and TNF-α in the MS patients with depression were higher than that in the MS patients without depression.73.3% of the MS patients with depression were treated effectively.The concentration of IL-1β,IL-6 and TNF-α in the MS patients with depression was reduced after antidepressant treatment.Conclusion The MS patients with depression have correlation with cytokines of IL-1β,IL-6 and TNF-α.The results may suggest that the role of cytokines may activate the occurrence of depression in MS.