西洋参对小鼠病毒性心肌炎的疗效及机制

目的:探讨西洋参(Panax quinquefolium)对BALB/C小鼠Coxsackie B_3病毒性心肌炎的治疗作用。方法:雄性4周龄BALB/C小鼠腹腔接种CVB_3病毒液,建立VMC模型,接种30min后用西洋参煎剂灌胃每日1次,持续最长至4周。观察小鼠存活率、心肌病理改变、心肌内病毒滴度、心肌细胞凋亡坏死率、外周血T细胞亚群及抗心肌抗体的改变。结果:西洋参治疗组比病毒感染组存活率提高,心肌组织病理改变恢复加快,心肌细胞凋亡坏死率减低及外周血T细胞亚群比例改善,自身抗体减少(P<0.05)。结论:西洋参对CVB小鼠有较好的治疗作用。晚期效果好于黄芪。

EFFECT AND MECHANISM OF MICE VIRAL MYOCARDITIS TREATED BY PANAX QUINQUEFOLIUM

Objective: To investigate the effect of Panax quinquefolium (PQ) on mice myocarditis caused by CVB.v Methods: Male BALB/C mice was inoculated 0. 1ml108TCID30/ml CVB3 intraperitoneally and administered 5 mg/g Panax quinquefolium for 28 days after viral inoculation. The survival rate, histopathologic changes of my -ocardium.the virus liter in myocardium.the ratio of apoptosis and necrosis of myocytes .T-lymphocyte susets profile and ACA-IgG were observed. Results: PQ can improve the survival rate. lighten myocardial .histopathologic changes .reduce the percentage of apoptosis and necrosis of myocytes .ameliorate the decrease of T-lymphocyte subsets , lessen positive rate of ACA-IgG. Conclusions: PQ has some curative effects on CVB3 murine myocarditis. which is better than that of Astragalus in late time.