| 慢性移植物抗宿主病的发病机制及其相关问题最新研究进展 |
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| 引用本文： | 李喜梅,朱恒,周凡,张毅.慢性移植物抗宿主病的发病机制及其相关问题最新研究进展[J].中国实验血液学杂志,2014(2):549-554. |
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| 作者姓名： | 李喜梅 朱恒 周凡 张毅 |
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| 作者单位： | [1]辽宁医学院沈阳军区总医院研究生培养基地,辽宁沈阳110016 [2]中国人民解放军军事医学科学院基础医学研究所细胞生物学研究室,北京100850 |
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| 基金项目： | 国家自然科学基金面上项目（81371945,81371945,31070996,31171084）;国家自然科学基金青年项目（81101342）;北京市自然科学基金面上项目（7132133） |
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| 摘 要： | 异基因造血干细胞移植（allogenichematopoieticstemcelltransplantation，allo—HSCT）是目前治疗造血系统各种恶性疾病或非恶性增殖性疾病的有效方法，但是移植物抗宿主病（graftversushostdisease，GVHD）的发生限制了造血干细胞移植的成功率，其中慢性移植物抗宿主病（chronicgraftversushostdisease，cGVHD）是影响造血干细胞移植后受者长期生存率和生活质量的主要因素。本文从胸腺、细胞因子、T淋巴细胞各亚群和B淋巴细胞及其分泌的抗体四个方面对cGVHD的发病机理及相关领域的最新研究进展作一综述。
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| 关 键 词： | 造血干细胞移植 慢性移植物抗宿主病 发病机制 |
Latest Research Progress on Pathogenesis of Chronic Graft versus Host Disease and Its Related Problems --Review |
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| LI Xi-Mei,ZHU Heng,ZHOU Fan,ZHANG Yi.Latest Research Progress on Pathogenesis of Chronic Graft versus Host Disease and Its Related Problems --Review[J].Journal of Experimental Hematology,2014(2):549-554. |
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| Authors: | LI Xi-Mei ZHU Heng ZHOU Fan ZHANG Yi |
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| Institution: | 1 Base for Training Postgranduates, Shengyang Military Command Gerenal Hospital, Liaoning Medical College, Shengyang 11 0016, Li- aoning Province, China ; 2 Department of Cell Biology, Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Bei- jing 100850, China) |
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| Abstract: | Allogeneic hematopoietic stem cell transplantation （allo-HSCT） is an effective method for the treating of malignant diseases of hematopoietic system or non-malignant proliferative diseases, but the occurrence of graft-versus- host disease （GVHD） limits the success rate of hematopoietic stem cell transplantation. Moreover, chronic graft-versus- host disease （cGVHD） is the main factor affecting the long-term survival rate and life quality of recipient after hematopoietic stem cell transplantation. In this article, the latest research progress of the pathogenesis of cGVHD and related problems are reviewed from the thymus, cytokines, T lymphocyte subsets, B lymphocytes and its secreted antibody. |
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| Keywords: | hematopoietic stem cell transplantation chronic graft-versus-host disease pathogenesis |
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