| 军人创伤后应激障碍患者关联性负变与失配性负波的变异 |
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| 引用本文： | 甘景梨,高存友,杨代德,张伟红.军人创伤后应激障碍患者关联性负变与失配性负波的变异[J].第四军医大学学报,2004,25(22):2109-2111. |
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| 作者姓名： | 甘景梨 高存友 杨代德 张伟红 |
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| 作者单位： | 解放军91医院全军精神疾病防治中心,河南焦作,454003;解放军91医院全军精神疾病防治中心,河南焦作,454003;解放军91医院全军精神疾病防治中心,河南焦作,454003;解放军91医院全军精神疾病防治中心,河南焦作,454003 |
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| 摘 要： | 目的: 探讨军人创伤后应激障碍(PTSD)患者关联性负变(CNV)及失配性负波(MMN)的变异.方法: 应用美国Nicolet Bravo脑诱发电位仪,采用光和声成对刺激、反应时间以及听觉靶-非靶刺激序列技术,检测66例PTSD和36名正常人(NC)的CNV及MMN.结果: (1)CNV: M1潜伏期PTSD组(503.4±139.2) ms]长于NC组(420.1±123.6) ms;P<0.01],M2波幅PTSD组(18.9±7.9) μV]高于NC组(11.7±5.8) μV;P<0.01],指令信号后负变化(PINV)的出现率PTSD组(39%)高于NC组(3%;P<0.01).(2)MMN: 潜伏期PTSD组(214.2±25.7) ms]长于NC组(193.7±22.6) ms;P<0.01],波幅PTSD组(8.5±1.8) μV]高于NC组(5.4±2.2) μV;P<0.01].结论: CNV与MMN的变异特点可作为PTSD辅助诊断的脑电生理学标志.
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| 关 键 词： | 军事人员 应激障碍 创伤后 伴随负变化 失配性负波 |
| 文章编号： | 1000-2790(2004)22-2109-03 |
| 修稿时间： | 2004年9月7日 |
Variations of contingent negative variations and mismatch negative in patients with post traumatic stress disorder |
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| GAN Jing-Li,GAO Cun-You,YANG Dai-De,ZHANG Wei-Hong Mental Diseases Prevention & Treatment Center of Chinese PLA,Chinese PLA st Hospital,Jiaozuo ,China.Variations of contingent negative variations and mismatch negative in patients with post traumatic stress disorder[J].Journal of the Fourth Military Medical University,2004,25(22):2109-2111. |
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| Authors: | GAN Jing-Li GAO Cun-You YANG Dai-De ZHANG Wei-Hong Mental Diseases Prevention & Treatment Center of Chinese PLA Chinese PLA st Hospital Jiaozuo China |
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| Institution: | GAN Jing-Li,GAO Cun-You,YANG Dai-De,ZHANG Wei-Hong Mental Diseases Prevention & Treatment Center of Chinese PLA,Chinese PLA 91st Hospital,Jiaozuo 454003,China |
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| Abstract: | AIM: To investigate the variations of contingent negative variations (CNV) and mismatch negative (MMN) in patients with post-traumatic stress disorder (PTSD). METHODS: Sixty-six cases of patients with PTSD and 36 normal controls (NC) were involved.The CNV and MMN were recorded with Nicolet Bravo Instrument.RESULTS: Compared with NC group, PTSD group showed delayed M 1 latency and increased M 2 amplitude (P<0.01). The post imperative negative variation (PINV) emergence rate of CNV in PTSD group was significant different from that in NC group (P<0.01). Compared with NC group,PTSD group showed further prolonged MMN latency and higher increased MMN amplitude (P<0.01). CONCLUSION: The characteristics of CNV and MMN can served as a physiological index in diagnosing of PTSD. |
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| Keywords: | military personnel stress disorders post-traumatic contingent negative variation mismatch negativity |
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