脂肝清胶囊对酒精性肝损伤的保护作用

目的探讨脂肝清胶囊对酒精性肝损伤的保护作用。方法采用白酒复制大鼠肝损伤模型,脂肝清胶囊按高、低剂量灌胃,连续8周,测定血清谷草转氨酶(AST)、谷丙转氨酶(ALT)及三酰甘油(TG)的含量,并观察肝脏的病理组织学改变。结果脂肝清胶囊高、低剂量组可显著降低大鼠血清AST、ALT及TG含量,与肝损伤模型组比较有显著性差异(P<0.01或0.05);肝组织病理学改变较肝损模型组显著减轻(P<0.05)。结论脂肝清胶囊对大鼠酒精性肝损伤具有保护作用,呈一定的量效关系。

Protective effect of Zhiganqing Capsule in alcoholic liver injure

Objective It is to approach the protective effect of Zhiganqing Capsule in alcoholic liver injure.Methods Liver injure rat models were made by alcohol,the high-dose and lowdose Zhiganqing Capsule were intragastric administration continuously for 8 weeks,the contents of AST,ALT and TG were detected,and the pathology change of hepatic was observed.Results Zhiganqing Capsule of the high-dose group and the low-dose group can obviously lowerdown the contents of AST,ALT and TG compared with the model group(P<0.05 or P<0.01),and the pathology change of hepatic was obviously improved than the model group(P<0.05).Conclusion Zhiganqing Capsule have protective effect in alcoholic liver injure rats,and there is a dose-effect relationship.