我院420例药品不良反应报告分析

目的了解药品不良反应（ADR）的发生特点，促进-临床合理用药。方法对420例ADR报告分别从年龄、给药途径、涉及药物种类、ADR临床表现等进行回顾性分析。结果420例ADR中60岁以上的老年患者较多，占总例数的31．91％（134例）；给药方式以静脉滴注为多，占83．10％（349例）；导致ADR的药品以抗菌药物最多，占总数的38．33％（161例），其中以喹诺酮类、头孢菌素类抗菌药物最为常见；临床表现以皮肤及附件损伤最多，占总例数的38．81％（163例）。结论临床应重视ADR报告和监测工作，合理使用抗菌药物，避免或减少ADR发生。

Analysis of 420 Cases of Adverse Drug Reaction in Our Hospital

Objective To understand the features of adverse drug reaction（ADR） and to promote the clinical rational administration. Methods To adopt the retrospective analysis to observe age, administration route and concerning categories of drug in 420 ADR reports during July 2007-March 2008. Results Among 420 cases of ADR, most were the senile patients, whom accounted for 31.91% （134cases）; the way of intravenous drip occupied 83.10% （349 cases）; ADR caused by antibacterials was the most, which accounted for 38.33% （161 cases）. Antibacterials of quinolone and cephalosporin were most common. The most of clinical manifestation were the damages of skin and its appendages, which occupied 38.81% （163 cases）. Conclusion Attention should be paid to ADR reports and monitoring work in clinic, antibacterials should be rationally utilized to avoid or relieve the occurrence of adverse drug reaction.