| 新光敏剂PSD—007的光毒反应 |
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| 引用本文： | 袁伯俊,李保春,沈念慈. 新光敏剂PSD—007的光毒反应[J]. 第二军医大学学报, 1984, 0(4) |
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| 作者姓名： | 袁伯俊 李保春 沈念慈 |
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| 作者单位： | 第二军医大学抗疟药研究室(袁伯俊，李保春)，第二军医大学抗疟药研究室(沈念慈) |
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| 摘 要： | 本文报道新光敏剂PSD-007及美国和国产(北京制药工业研究所的血卟啉衍生物(HPD)在2·5mg/kg及其以上剂量静脉注射可致小鼠的光毒反应。光毒反应的强度随剂量增加而加重。在等重剂量条件下。PSD-007所致光毒反应较美国和国产HPD为轻;轻度光毒反应的恢复也以PSD-007为快。
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| 关 键 词： | 血卟啉 光敏剂 光化学疗法 光敏性疾病(光毒反应) |
PHOTOTOXIC EFFECT OF THE NEW PHOTOSENSITIVE AGENT PSD-007 |
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| Yuan Bojun,et al Laboratory for Antimalarial Drug Research. PHOTOTOXIC EFFECT OF THE NEW PHOTOSENSITIVE AGENT PSD-007[J]. Former Academic Journal of Second Military Medical University, 1984, 0(4) |
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| Authors: | Yuan Bojun et al Laboratory for Antimalarial Drug Research |
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| Abstract: | PSD-007 is a new photosensitizing agent whose phototoxicity was demonstrated in mice in comparison with other two agents, i. e. hematoporphyrin derivatives (HpD) produced in USA and in our country (Beijing) .The phototoxic reaction was characterized by erythema and necrosis of ears. The results of the administration of 2.5, 5.0, and 10.0mg/kg of PSD-007 and PSD-007 iv. were reported. The extent of their phototoxic severity was dose-related. The demonstrable phototoxicity of PSD-007 was lower than that of the two others. Moreover, the recovery from light phototoxic reaction was earlier than that of the two others |
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| Keywords: | hematoporphyrin photosensitizer photochemotherapy photosensitive disorders (phototoxicity) ultraviolet ravs |
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