心理干预对糖尿病合并抑郁患者SDS、SAS评分及CRP、Hcy水平的影响研究

目的探讨心理干预对糖尿病合并抑郁患者SDS、SAS评分及CRP、Hcy水平的影响。方法选择秦皇岛市耀华医院2009年1月-2010年12月收治的糖尿病合并抑郁患者72例,随机分为观察组36例和对照组36例,对照组采用常规治疗,观察组在对照组的基础上加强心理干预治疗,比较两组患者的恢复情况。结果治疗前,两组患者的抑郁自评量表（SDS）与焦虑自评量表（SAS）评分比较,差异无统计学意义（P〉0.05）;两组患者的C反应蛋白（CRP）及同型半胱氨酸（Hcy）水平均明显升高（P〈0.05）,组间差异无统计学意义（P〉0.05）。治疗后,两组患者的SDS、SAS评分均明显降低,以观察组改善更为明显,组间差异均有统计学意义（P〈0.05）;而两组患者的CRP、Hcy水平也明显降低,以观察组改善更为明显,组间差异均有统计学意义（P〈0.05）。结论心理干预治疗可以改善糖尿病合并抑郁患者的抑郁情绪,患者的CRP、Hcy水平与SDS、SAS评分改善情况保持一致,关系密切,应得到临床关注。

Study on Influence of Psychological Intervention on SDS, SAS Score and CRP, Hcy Levels of Patients with Diabetes Mellitus and Depression

Objective To evaluate the influence of psychological intervention on SDS,SAS score and CRP,Hcy levels of patients with diabetes mellitus complicated by depression.Methods Seventy-two patients with diabetes mellitus complicated by depression hospitalized in Yaohua Hospital of Qinhuangdao from January 2009 to December 2010 were randomly divided into observation group and control group(each n=36).The control group received routine treatment,while the observation group strengthened psychological intervention treatment on the basis of the control group.And the recovery data of the two groups were compared.Results Before the treatment,there was no statistically significant difference in the scores of self-rating depression scale(SDS) and self-rating anxiety scale(SAS) between the two groups(P>0.05).The levels of C-reactive protein(CRP) and homotypic cysteine(Hcy) of the two groups were both significantly increased(P<0.05),and the difference was statistically significant between the two groups(P>0.05).After the treatment,the SDS,SAS scores of two groups were both significantly decreased,the observation group improved more significantly,and the differences were statistically significant between the two groups(P<0.05).The levels of CRP and Hcy in two groups were significantly decreased,the observation group improved more significantly,and the differences were statistically significant between the two groups(P<0.05).Conclusions Psychological intervention can improve depression in patients with diabetes mellitus complicated by depression.The improvement of the CRP and Hcy levels is consistent with and closely related to the improvement of the scores of SDS and SAS in the patients.Psychological intervention should get more attention in clinical practice.