| 多指标联合检测对慢性活动性乙型肝炎患者肝脏损伤的诊断价值 |
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| 引用本文： | 吴兴文,刘长光,罗佳2. 多指标联合检测对慢性活动性乙型肝炎患者肝脏损伤的诊断价值[J]. 实用预防医学, 2011, 18(12): 2269-2271 |
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| 作者姓名： | 吴兴文 刘长光 罗佳2 |
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| 作者单位： | 1. 湖南省株洲市北雅医院 湖南株洲412000
2. 株洲市二医院 |
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| 摘 要： | 目的探讨不同的检测项目组合模式对慢性活动性乙型肝炎患者肝脏损伤的诊断价值。方法检测慢性活动性乙型肝炎患者血清谷丙转氨酶（ALT）、前白蛋白（PAB）、总胆汁酸（TBA）、超敏C-反应蛋白（hs-CRP）及D-二聚体（DD）含量并进行分组研究。结果血清ALT、TBA及DD在正常对照组与患者组间差异有统计学意义,且随着肝脏炎症程度的增加而逐渐升高,PAB则正好相反。血清hs-CRP在肝脏炎症分级为G1和G2级时的含量明显高于对照组,但在G3及G4级其含量降至正常对照组水平。将检测项目进行不同的组合并研究组合后检测结果对肝脏损伤的诊断价值,表明随着组合项目的增多,对肝脏损伤的诊断特异性增加,灵敏度有所下降,但PAB＋TBA、PAB＋DD、TBA＋DD三种组合模式,特别是TBA＋DD组合模式在检测灵敏度下降不明显的情况下能显著增加检测的特异性。结论合理选择项目组合对提高慢性活动性乙型肝炎肝脏损伤诊断的特异性具有一定的帮助。
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| 关 键 词： | 慢性活动性肝炎 感染 乙型肝炎病毒 诊断 |
Clinical Value of Markers Combination Measurement in Diagnosis of Liver Impairment in Chronic Active Hepatitis B Patients |
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| WU Xing-wen,LIU Chang-guang,LUO Jia. Clinical Value of Markers Combination Measurement in Diagnosis of Liver Impairment in Chronic Active Hepatitis B Patients[J]. Practical Preventive Medicine, 2011, 18(12): 2269-2271 |
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| Authors: | WU Xing-wen LIU Chang-guang LUO Jia |
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| Affiliation: | WU Xing-wen,LIU Chang-guang,LUO Jia(Beiya Hospital of Zhuzhou City,Zhuzhou 412000,Hunan,China) |
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| Abstract: | Objective To explore the value of different integrated modes of laboratory testing items in the diagnosis of liver impairment in chronic active hepatitis B patients. Methods The detection of serum glutamic pyruvic transaminase(ALT),prealbumin (PAB),total bile acid(TBA),high-sensitive c-reaction protein(hs-CRP) and D-Dimer(DD) was carried out and the results were analyzed. Results There were statistically significant differences in the contents of ALT,TBA,and DD between the patients and control group,and the... |
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| Keywords: | Chronic active hepatitis Infection Hepatitis B virus Diagnosis |
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