西酞普兰对老年脑卒中后抑郁及神经功能康复的影响

目的探讨西酞普兰对老年脑卒中后抑郁及神经功能康复的影响。方法将老年脑卒中后抑郁病人随机分为观察组（西酞普兰合并常规脑血管病治疗）及对照组（常规脑血管病治疗），各43例。分别于治疗前及治疗后第2、4、8及12周末进行Hamilton抑郁量表（HAMD）、神经功能缺陷及日常生活能力（ADL）评定。结果经过12周的治疗后，观察组病人的HAMD及神经功能缺陷评分均极明显低于对照组（P〈0．01）；而ADL评分则极明显高于对照组（P〈0．01）。结论西酞普兰不仅有助于改善老年脑卒中后抑郁，而且有利于神经功能的康复，提高其日常生活能力。

The effects of citalopram on post-stroke depression and neurological rehabilitation in the elderly

]Objective To explore the effects of citalopram on post-stroke depression and neurological rehabilitation in the elderly.Method There were 86 post-stroke depression cases.They were divided into 2 groups:All of them were on the regular treatment of cerebrovascular disease.43 cases of observed group taking citalopram once every morning about 20 mg daily.All of cases were evaluated according to the HAMD score,neurological function impairment and ADL before treatment and 2~ nd,4~ th,8~ th,12~ th week after the treatment.Results After 12 weeks treatment,the scores of HAMD and the neurological function impairment in observed group were lower than those in controlled group (P<0.01).The scores of ADL observed group were higher than those in controlled group (P<0.01).Conclusions Citalopram is in favor of not only control the post-stroke depression in the elderly effectively but also rehabilitating neurological function,improving the living ability.